Speaker
Descrizione
Magnetic particles are widely utilised in clinical research; however, conventional systems rely upon relatively large, micrometre-sized beads. Although the deployment of ultrasmall nanoparticles—comparable in scale to biological molecules—presents significant advantages, their control is severely hindered by thermal fluctuations. At ISMN, we have developed a magnetic approach that enables the reliable manipulation of sub-20 nm nanoparticles [1]. This advancement transforms magnetic nanoparticles into active, functional materials capable of performing analytical operations such as selective capture, purification, transport, concentration, sensing, and the controlled delivery of biomolecules. To demonstrate its utility, this technology has been applied to the highly sensitive detection of Alzheimer’s disease biomarkers [2], as well as the controlled delivery of neural morphogens to stem cells [3].
References
[1] Surpi A. et al. Versatile magnetic configuration for the control and manipulation of superparamagnetic nanoparticles. Scientific Reports. (2023) 13:5301 doi.org/10.1038/s41598-023-32299-9.
[2] Surpi A. et al. Magnetic separation and concentration of Aβ1–42 molecules dispersed at the threshold concentration for Alzheimer’s disease diagnosis in clinically-relevant volumes of sample. Journal of Nanobiotechnology. (2023) 21:329 doi.org/10.1186/s12951-023-02095-8.
[3] Surpi A. et al. Amphiphilic cyclodextrin-based nanocarriers for magnetic delivery of a morphogen in microfluidic environments. Materials Advances. (2025) 6: 6775 doi.org /10.1039/d5ma00374a.
| Giovane Ricercatore (under 40) | No |
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