Speaker
Descrizione
Exposure to ionizing radiation presents one risk factor in human space flight. To protect astronauts on future long duration missions better, we have to address three scientific frontiers, namely (i) elucidation of the molecular damage mechanisms, (ii) identification of tissue specific responses and (iii) rationalizing our understanding of radioprotectant molecules. Similarly, predictive markers for genotype specific responses still lack for ideal future classification. By assessing classification into radiosensitivity (acute response) or radiosusceptibility (cancer onset likelihood) or radiodegeneration (aging effects) across over 11,000 in-vitro and in-vivo studies, we present an ontology of key terms and one example of a mechanistic damage cascade that hinges on chemical changes in proteins. This we can call “molecular radiation injuries”. A brief overview of all possible such molecular radiation injuries, with focus on oxidation-induced protein alterations, is given.
