Vision is the most dominant human sense and the visual system represents a sensitive marker of biological and physical insults. Here, we exploited this system to compare the effects of ultra-high dose rate radiotherapy (FLASH) and conventional dose rate irradiation (CONV) in healthy C57BL/6 mice and in a preclinical models of ocular melanoma and glioblastoma. Irradiations were performed with a...
FLASH radiotherapy (FLASH-RT) delivers radiation at ultra-high dose rates (UHDRs), achieving strong antitumor efficacy while minimizing normal tissue toxicity. However, the cellular and metabolic mechanisms underlying this ‘FLASH effect’ remain unclear. Here, we compared the impact of FLASH versus conventional (CONV) irradiation (8 Gy in vitro) in glioma GL261 cells and healthy primary glial...
