Workshop on Advanced Radiotherapies and Diagnostic in Oncology

Sessione

SESSION 4

13 mar 2026, 11:30

Auditorium (Edificio A) (CNR - Area della Ricerca di Pisa)

76. WP4-The Sparing Effect of Electron FLASH Radiotherapy on Murine Skin: Molecular Mechanisms and Systemic Responses

Giulia FURINI (CNR-IFC)

13/03/26, 11:30

Background and Aim: The molecular mechanisms underlying the FLASH effect remain largely unknown. We previously demonstrated that electron FLASH radiotherapy (FLASH-RT) achieves tumor control comparable to conventional radiotherapy (CONV-RT) in a murine melanoma model, while significantly reducing damage to surrounding skin. Here, we investigated the molecular and histological correlates of...

77. WP4-Preserving Tissue Integrity: Differential Impact of FLASH and Conventional Radiotherapy on White Adipose Tissue

Gaia SCABIA (CNR Istituto di Fisiologia Clinica)

13/03/26, 11:45

Background: Subcutaneous white adipose tissue (scWAT) is a major energy reservoir and an active endocrine organ. Owing to its widespread distribution, scWAT is inevitably exposed during conventional (CONV) radiotherapy (RT). Although RT remains a cornerstone of cancer treatment, its therapeutic efficacy is limited by toxicity to surrounding healthy tissues. Ultra-high dose rate (FLASH) RT has...