Radiotherapy has undergone profound technological and conceptual evolution over the past decades, becoming increasingly precise, image-guided, and patient-centric. This presentation provides a comprehensive overview of the current state of the art in radiotherapy from a clinical-physics perspective, highlighting how established standards are continuously refined through advances in medical...
Ionizing radiation triggers a sequence of physical, physico-chemical and chemical events from
femtoseconds to milliseconds before entering a biological response window that extends from
seconds to days and years. Within this cascade, superoxide dismutases (SODs) in living cells critically regulate the conversion of superoxide to hydrogen peroxide (H2O2), thereby shaping downstream redox...
Ultrahigh-intensity laser systems now enable the generation of particle beams with instantaneous dose rates reaching 10⁷–10¹² Gy/s and pulse durations down to the femtosecond regime. The Extreme Light Infrastructure (ELI) is emerging as a unique open-access platform where such laser-driven protons, ions, electrons, and neutrons can be systematically investigated for radiobiology and medical...
