While radiotherapy is a key component in the management of more than 80% of breast cancer,
the dose required to achieve a high probability of tumour control can overlap with the rates of
radiation-induced normal tissue side effects, hindering effective treatment. FLASH-RT, delivered
at ultra-high dose rates, was shown to generate comparable anti-tumour effects compared to
conventional...
Laser-driven ion acceleration via ultra-intense laser–matter interaction has rapidly progressed in recent years, demonstrating the capability to generate high-current, short-pulse ion beams with unique temporal and spectral characteristics. These beams, inherently different from those produced by conventional accelerators, open new perspectives for multidisciplinary applications, particularly...
We have recently developed novel irradiation platforms capable of delivering multi-Gy doses in a single pulse with durations ranging from 20 picosecond down to 150 femtoseconds (mean dose-rates up to 10^13 Gy/s). Irradiation of a series of normal and tumoral cell lines, in both 2D and 3D geometries, consistently indicate a significantly different response when compared to conventional and...
