Uveal melanoma represents the most common primary intraocular malignancy in adults.
Current treatment strategies include eye-preserving stereotactic radiotherapy (SRT) and
enucleation in advanced-stage disease. In this study, we investigate the feasibility of lowenergy
electron ultra-high dose-rate radiotherapy (eFLASH-RT) as a novel treatment
modality for localized uveal melanoma. The...
Whole brain radiotherapy (WBRT) remains an essential treatment for brain metastases and primary intracranial malignancies, but conventional radiotherapy (CONV-RT) incidentally exposes ocular structures to radiation, potentially leading to vision-threatening complications. FLASH radiotherapy (FLASH-RT) delivers ultra-high dose rates (≥40 Gy/s) in milliseconds, compared to CONV-RT where the dose...
Laser-accelerated electron beams in the Very High-Energy Electron (VHEE) range are receiving increasing interest for biomedical applications. Furthermore, compact accelerator systems for the exciting field of FLASH radiotherapy may be made precisely accessible by laser-driven VHEE beams. Nevertheless, radiobiology experiments carried out using laser-driven beams require the real-time knowledge...
The generation of high-power, ultrashort pulsed electron beams is a key characteristic of
modern radiotherapy techniques based on the FLASH effect.
One of the most promising techniques in this field is Laser-Linacs (LL), which is based on the
Laser Wakefield Acceleration (LWFA) process. In this process, a high-power, ultra-short laser
pulse is focused into a gas-jet target to generate...
