The presentation will briefly provide an update about spoke 5 (IMPLEMENTING INNOVATION FOR HEALTHCARE AND WELL-BEING) activities with a focus on the medical device regulation tasks.
Various in vivo studies proved that the FLASH treatment results in a decrease of radiation-induced normal tissue toxicity, compared to conventional treatment, while having the same biological effect on tumoral tissue.
The aim of this study is to verify the possibility of using FLASH electron Radiotherapy as an alternative treatment modality for localized uveal melanoma. This is a highly...
L’obiettivo generale del WP8 è quello di fornire radiofarmaci innovativi PET, per uso clinico, da utilizzare nella diagnosi e nel follow-up dei gliomi e di altre patologie oncologiche.
L’officina farmaceutica produce quotidianamente i due radiofarmaci (18F-FDG and 18F-FColina) previsti nel milestone 2 con le seguenti Marketing Authorizations:
• Fluorocolina (18F) Curium Italy 225 MBq/mL...
In this presentation, the deliverables 1.5.4, 1.5.5, 1.5.6, 1.5.7 and 1.5.8 will be discussed.
The ElectronFlash linac performances have been characterized using both active and passive dosimeters and the reference conditions have been established.
We developed and validated, trough experimental data, a framework based on MonteCarlo simulations tuned with the ElectronFlash main parameters....
In questa presentazione verrò fornito un aggiornamento sullo sviluppo della piattaforma per lo storage e l’analisi dei dati nel progetto THE. Verrà introdotto un prototipo iniziale basato su XNAT, che abbiamo sviluppato sfruttando l’infrastruttura dell’INFN e collaborando anche con lo Spoke 4, per gestire immagini e dati di microscopia. Verrà mostrata l’interfaccia relativa a questo prototipo...
In phenomenological stochastic models of the biological cellular effect of ionizing radiation, e.g. the multiple target multiple hit model (MTMH), one uses the concept of threshold - the effect happens if at least M critical cellular targets are hit by at least N ionizing particles each, the effect doesn’t happen otherwise. In these models, a notable sigmoidal shape of the biological effect...
Over the past ten years, laser plasma accelerators (LPA) have shown remarkable progress, influenced in part by advances in laser technology. Their ability to produce quasimonoenergetic electron beams with energies ranging from tens of MeV to tens of GeV in just a few millimeters to centimeters brought LPA to the attention of many scientific and industry fields. Arguably the most important of...
This study presents the experimental advancements in the generation and dosimetric characterization of laser-plasma accelerated Very High Energy Electron beams (100–250 MeV) for radiobiological applications.
These beams, known for their deep tissue penetration and reduced sensitivity to anatomical inhomogeneities, have been studied to evaluate their potential in advanced radiotherapy...
Radiotherapy is one of the most effective anti-tumor therapies, used in more than 60% of cancer patients at some point in their oncological treatment to eliminate/reduce the size of the tumor. At present, conventional radiotherapy (CONV-RT), the main approach used in clinic, presents some limitations, including the dose fractionation into several daily sessions and the risks for the...
Radiotherapy (RT) is a widely used treatment for various cancers. While it effectively targets cancerous cells, RT also damages the surrounding healthy tissue, particularly in sensitive regions like the central nervous system. This collateral damage poses significant challenges in maintaining neurological function.
Ultra-high dose-rate FLASH radiotherapy (FLASH-RT) has emerged as a promising...
Uveal melanoma is the most common primary intraocular malignancy in adults. Eye enucleation has long been the gold standard for treatment but adverse effects have shifted recommendations toward eye preservation and radiotherapy. This can also lead to complications like radiation retinopathy, retinal detachment and optic neuropathy. To overcome the limitations of conventional radiotherapy...
Second-harmonic generation (SHG) microscopy is based on a coherent non-linear scattering process that allows high-resolution deep-tissue imaging of biological structures having high hyperpolarizability and structural anisotropy. For this reason, SHG represents a powerful tool for imaging collagen and probing its hierarchical organization from molecular scale up to tissue architectural level....
Ultra-high dose-rate FLASH radiotherapy (FLASH-RT) has emerged as a promising approach in oncology, potentially enhancing the therapeutic index by minimizing normal tissue toxicity while maintaining anticancer efficacy compared to conventional radiotherapy (CONV-RT). However, the radiobiological effects on cranial radiotherapy are yet to be fully understood. This study investigates the in vivo...
Aim
We aimed to assess and compare the effects of FLASH-RT and CONV-RT on tumor growth in a melanoma model and on skin toxicity and systemic responses in healthy mice.
Methods
A melanoma model was established by injecting B16F10 cells intradermally into the left leg of mice. After five days, mice were irradiated with either 19 Gy or 35 Gy using FLASH (940 Gy/s) or CONV modes...
Cancer theragnostics is an emerging field of nuclear medicine that allows the integration of imaging and radiotherapy. It is based on the use of a pair of radiopharmaceuticals with the same molecular structure, one containing a positron-emitting isotope (such as fluorine-18 (18F) or gallium-68 (68Ga)) for PET imaging, aiding disease staging, therapy selection and monitoring. The other...
In this project we focused on the design, synthesis, and optimization of novel molecules of biomedical interest with particular relevance in the tumor microenvironment. [1] The developement of new strategies to counteract such a disease is of paramount importance. Among synthetic strategies known to date, the use of Multi-Target Directed Ligands (MTDLs) has emerged as particularly effective,...
