Presentation materials
In questa presentazione verrò fornito un aggiornamento sullo sviluppo della piattaforma per lo storage e l’analisi dei dati nel progetto THE. Verrà introdotto un prototipo iniziale basato su XNAT, che abbiamo sviluppato sfruttando l’infrastruttura dell’INFN e collaborando anche con lo Spoke 4, per gestire immagini e dati di microscopia. Verrà mostrata l’interfaccia relativa a questo prototipo...
In phenomenological stochastic models of the biological cellular effect of ionizing radiation, e.g. the multiple target multiple hit model (MTMH), one uses the concept of threshold - the effect happens if at least M critical cellular targets are hit by at least N ionizing particles each, the effect doesn’t happen otherwise. In these models, a notable sigmoidal shape of the biological effect...
In the last decades, Laser plasma acceleration (LPA) has seen a growing interest both for pure research purposes but also for being employed in applications. One of the key features is the possibility to reach high acceleration gradients, resulting in compact accelerators and reduced costs. Laser Wake-Field Acceleration (LWFA) is routinely used to produce energetic electrons and, by properly...
Accurately measuring the energy of very high-energy electron (VHEE) beams is crucial if they are to be considered for applications. Laser-driven electrons are notoriously known for beam pointing and divergence variations from shot-to-shot. We have developed a spectrometer system that accurately measures the energy, by simultaneously correcting for pointing and charge. We conducted laser...
Over the past ten years, laser plasma accelerators (LPA) have shown remarkable progress, influenced in part by advances in laser technology. Their ability to produce quasimonoenergetic electron beams with energies ranging from tens of MeV to tens of GeV in just a few millimeters to centimeters brought LPA to the attention of many scientific and industry fields. Arguably the most important of...
This contribution presents the development of a 3D online dosimeter based on a plastic scintillating monolithic block, imaged with cameras to reconstruct the three-dimensional dose distribution using a tomographic algorithm. The study primarily relies on simulations to investigate the feasibility and performance of the proposed system.
The simulated detector consists of a 10 cm...
This study presents the experimental advancements in the generation and dosimetric characterization of laser-plasma accelerated Very High Energy Electron beams (100–250 MeV) for radiobiological applications.
These beams, known for their deep tissue penetration and reduced sensitivity to anatomical inhomogeneities, have been studied to evaluate their potential in advanced radiotherapy...
This research investigates the radiobiological response and dose-dependent chromosomal damage in human lymphocytes exposed to very high-energy electron (VHEE) beams, employing the cytokinesis-block micronucleus (CBMN) assay—an internationally recognized biodosimetric method endorsed by the International Atomic Energy Agency (IAEA). Micronuclei (MN) are small, extranuclear bodies that form when...
