3° INCONTRO SULL’ECOSISTEMA TOSCANO PER L’INNOVAZIONE - SPOKE 1

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SESSION 1 - PROJECT MANAGEMENT "Preliminary"

SESSION 2 - SPOKE1: PROGRESS OF SUBPROJECTS "Preliminary"

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Overview: Cronoprogramma e milestones

Project management

SPOKE 5 - Update

Studi di imaging PET con radiotraccianti selettivi per la proteina FAP e le integrine per la valutazione del rimodellamento del microambiente tumorale in seguito a radioterapia ad altissime dosi.

Sub-project(1.1): Dosimetry with plastic scintilaltor in electron FLASH radiotherapy.

Sub-project(1.1): Toward a laser-driven VHEE radiotherapy: Monte Carlo simulations of transport and focalization.

Sub-project(1.2): Multi-scale modeling of high dose-rate irradiation: updates.

Sub-project(1.2): Requirements and specifications to configure an XNAT-based platform for data collection and processing within THE project.

Sub-project(1.3,1.4,1.5): A time line for animal studies: radiotheraphy on naïve and melanoma mouse models.

Sub-project(1.3,1.4,1.5): Anatomic and tissue characterization of melanoma model using high field MRI.

Sub-project(1.3,1.4,1.5): Creation of devices for optimizing in vitro experiments, beam modification and quantification of dose distribution.

Sub-project(1.3,1.4,1.5): Effects of conventional and flash radiotherapy on glioblastoma and melanoma cells

Sub-project(1.3,1.4,1.5): Evaluating the effects of irradiation on murine corneal collagen structures using two photon imaging.

Sub-project(1.3,1.4,1.5): Flash radiotherapy: a new approach for ocular melanoma.

Sub-project(1.3,1.4,1.5): Flash vs Conventional radiotherapy: melanoma cells and primary adipocytes response

Sub-project(1.3,1.4,1.5): The role of super-resolution microscopy in understanding the effects induced in vitro by different radiotherapy regimes

Sub-project(1.3,1.4,1.5): Visual system function as a read out of in-vivo radiotherapy.

Sub-project(1.6): Updates on optical imaging for Cerenkov dosimetry.

Sub-project(1.7): Design, optimization and synthesis of dual inhibitors against tumor-associated human Carbonic Anhydrases and Fibroblast Activation Protein (FAP-α) through the use of radiolabeling chelators.

Sub-project(1.7): Ongoing activities as part of WP 1.7.

Sub-project(1.8): Radiofarmaci per uso clinico: dalla produzione al trasferimento tecnologico.

Summary

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19/12/23

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