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This study presents the experimental advancements in the generation and dosimetric characterization of laser-plasma accelerated Very High Energy Electron beams (100–250 MeV) for radiobiological applications.
These beams, known for their deep tissue penetration and reduced sensitivity to anatomical inhomogeneities, have been studied to evaluate their potential in advanced radiotherapy applications.
The experimental work involved dosimetric measurements using stacks of EBT3 radiochromic films to map the dose distribution of a collimated electron beam with a 7 mm diameter. Dose delivery was evaluated for multiple ultra-high dose rate pulses. The characterization was performed to optimize irradiation and dose measurement for radiobiological samples.
3D-printed sample holders designed and produced for these experiments are described. These holders are adaptable to various containers (e.g., 0.5 ml Eppendorf tubes, 2 ml cryotubes, and 25 mm Petri dishes) and can integrate radiochromic dosimeters and stainless steel collimators to enhance irradiation precision. A motorized centering device enables precise sample positioning within the irradiation field. Additionally, a new holder with orthogonal angular movements and laser-guided alignment significantly improve beam alignment and irradiation homogeneity.
